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INSTITUTO DE INVESTIGACIONES BIOMEDICAS DE BARCELONA
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Notícies Agenda d'Activitats
Cognitive Enhancement in Health and Disease.
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data de publicació: 23/02/2012
NULLOrganizers:
Dr. Shira Knafo, Severo Ochoa Center for Molecular Biology (CSIC), Madrid, Spain.
Dr. César Venero, Universidad Nacional de Educación a Distancia (UNED), Madrid, Spain.
Dr....

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Cathepsin B overexpression due to Acid sphingomyelinase ablation promotes liver fibrosis in niemann-pick disease.
data de publicació: 02/01/2012
Fiber deposition, presence of foam cells and inflammation were decreased in ASMase-KO- livers after CtsB inhibition with Ca074Me. (A) Sirius Red staining of collagen fibers, (B) Hematoxylin & Eosin staining of liver sections after the corresponding treatments.Our recent work published in the Journal of Biological Chemistry: “Cathepsin B overexpression due to Acid Sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease” features the novel ...

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New antidepressant strategy based on acute siRNA silencing of 5-HT1A autoreceptors.
data de publicació: 24/10/2011
NULLDepression is a substantial public health problem; it is the second cause of disability worldwide. Our group report on a new treatment strategy based on the administration of small interference RNA (s...

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Expressió del gen c-fos induïda per fenciclidina en circuits tàlem-corticals.
data de publicació: 19/05/2011
Portada de la revista amb la imatge utilitzada.Investigadors del grup de Neurofarmacologia de Sistemes, dirigit per F. Artigas publiquen un article en Biological Psychiatry sobre l'activació de neurones talàmiques en models d'esquizofrènia. Una de...

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Una investigació demostra els efectes neuroprotectors de l'exercici en la malaltia d'Alzheimer.
data de publicació: 16/05/2011
Ratolins utilitzats en l'estudi.En aquest estudi experimental l'equip d'investigació de la Dra. Coral Sanfeliu demostra els beneficis de l'exercici físic en la malaltia d'Alzheimer.

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New role of Caveolin-1, a protein associated with cardiovascular diseases, lipodistrophy, diabetes, cancer and pulmonary fibrosis
data de publicació: 06/05/2011
Hepatocytes from wt and Cav-1 knockout mice exhibit enhanced susceptibility to Fas-mediated apoptosis and mitochondrial release of cytochrome c. GSH replenishment by GSH ethyl ester rescues Cav-1 deficient hepatocytes from Jo-2 induced apoptosis. Consequently, Cav-1 KO mice is more sensitive than wt mice to Fas-mediated steatohepatitis. For details please see Boch/Mari et al, Curr Biol 21: 681-686, 2011<br />www.ncbi.nlm.nih.gov/pubmed/21497090<br />Our recent work published on Current Biology: “Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility”, shows through in vivo and in vitro studies, a...

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TARGETING CHOLESTEROL PROTECTS FATTY LIVER AGAINST ISCHEMIA–REPERFUSION INJURY
data de publicació: 05/05/2011
The journal cover image shows in vivo two-photon confocal<br />microscopy of the liver of living mice during partial I/R<br />http://www.ncbi.nlm.nih.gov/pubmed/21145825Cholesterol, its accumulation in mitochondria in human fatty livers and correlation with graft failure, may represent a valuable tool to expand the pool of available organs for transplantation. Liver ...

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TNF-Receptors contribution to liver fibrosis.
data de publicació: 04/05/2011
Reduced liver damage and fibrosis in TNFR1 KO mice after bile duct ligation. H&E staining of liver sections (A) and serum transaminase levels (B) in wild-type and TNFR1-KO mice after BDL. TNF-á (C), MMP-9 and TIMP-1 (D), MMP-2 and pro-Colá1(I) (E), and á-SMA (F) mRNA expression in wild-type and TNFR1-KO livers after BDL. Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, live...

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ASTROCYTES IN AGING AND ALZHEIMER’S DISEASE
data de publicació: 23/09/2010
Pro-oxidant conditions trigger the toxic and inflammatory effects of amyloid beta in astrocytes. A-C) Human astrocyte cultures control, treated for 3 days with amyloid beta 42, and treated with amyloid beta and the prooxidant agents buthionine sulfoximine (BSO) and ferrous sulfate (Fe), respectively. BSO was added 24 h before the other agents. Astrocytes were stained with anti-GFAP antibody and nuclei were counterstained with bisbenzimide. Apoptotic nuclei show a bright fluorescence (arrows). Treatment with amyloid beta alone caused a slight change to an activated morphology. However, the mixed treatment with amyloid beta and pro-oxidant agents caused astrocyte activation and apoptosis. D-I) Hippocampus Ammon’s horn of rats submitted to 4 weeks of chronic icv infusion with vehicle, amyloid beta 40 and 42, and amyloid beta 42 and BSO and Fe. Immunohistochemical stain with anti-GFPA antibody and light counterstain with hematoxylin (D-F) and Fluoro-Jade B fluorescence staining (G-I), show morphological changes and reactivity of astrocytes (arrows). The higher astrocyte reactivity was caused by amyloid beta and prooxidant agents, where astrocytes also stained positive for Fluoro-Jade B. For details of treatment groups and dosing see full text. Scale bar = 20 m in A-C and 40 m in D-I.<br /><br />Alzheimer’s disease (AD) is the leading cause of dementia in people over 65. No cure has yet been found and current pharmacological therapy only temporarily ameliorates the symptoms. Age is the main r...

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SIMULTANEOUS PROJECTIONS FROM PREFRONTAL CORTEX TO DOPAMINERGIC AND SEROTONERGIC NUCLEI
data de publicació: 23/09/2010
Colocalization of 5-HT2A receptor mRNA hybridiation signal and cholera<br />toxin B subunit (CTB)-immunoreactivity in the medial prefrontal cortex after<br />injection of the tracer in the ventral tegmental area. (A) Clusters of<br />autoradiographic grains corresponding to 5-HT2A receptor mRNA-containing<br />cells are visible in layers II-VI at a low magnification; the strongest<br />signal is found in layer V neurons. The boxed area is shown in pannel B at a<br />higher magnification. (B) CTB-immunoreactivity (brown precipitate) can be<br />seen in some cells under the hybridization signal (red-blue double<br />arrowheads), whereas other cells display only 5-HT2A receptor mRNA signal<br />(blue arrowheads). (C) Detail of a CTB-immunoreactive neuron which lacks the<br />hybridization signal. (D) Detail of a double-labeled neuron containing<br />CTB-immunoreactivity and a strong 5-HT2A receptor mRNA hybridization signal.<br />(E) Detail of a cell profile showing 5-HT2A receptor mRNA signal without<br />CTB-immunoreactivity. Bars: 200 µm (A), 30 µm (B), 10 µm (C-E).<br />En un estudio publicado en la revista Cerebral Cortex, se muestra la existencia de receptores de serotonina 5-HT2A en una alta proporción de las neuronas piramidales de la corteza prefrontal que proye...

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Prof. José-Carlos Fernández-Checa Torres - Estudios Publicados en Noviembre 2009
data de publicació: 25/01/2010
Characterization of GD3 synthase-expressing Hep3B cells.<br />GD3 synthase overexpression in human hepatocellularcarcinoma Hep3B cells, alters the native pattern of glycosphingolipids featuring a predominant synthesis of GD3 from the endogenous GM3. GD3 synthase overexpression distributes to diverses intracellular structures, including mitochondria as revealed by the confocal imaging showing the colocalization of GD3 synthase (in red) with Mn-SOD (in green). This outcome, however, does not alter cell growth under normoxia, but sensitizes GD3 synthase overexpressing Hep3B cells to hypoxia. For more information, see the article by Lluis et al., PLoS ONE, 4, e8059, 2009.<br />Hepatocellular carcinoma is one of the leading causes of cancer-related death whose incidence is on the rise due to its association with obesity and nonalcoholic steatohepatitis. Currently the therapy...

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SEMINARIS IIBB 2012
data de publicació: 20/01/2012
''El Sistema Internacional de unidades: del metro al mol''

Dr. Oriol Bulbena.

25 maig 2012, 12:00h, Sala Miquel Servet.


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SEMINARIS IIBB 2012
data de publicació: 19/01/2012
''La micròglia com a diana terapèutica a processos neurodegeneratius''

Dra. Carme Solà.

22 juny 2012, 12:00h, Sala Miquel Servet.


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SEMINARIS IIBB 2012
data de publicació: 18/01/2012
''Let them in or keep them out: immune cells as new therapeutic agents for CNS diseases''

Dr. Jordi Serrats.

5 juliol 2012, 12:00h, Sala Miquel Servet.


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SEMINARIS IIBB 2012
data de publicació: 17/01/2012
''Estrategies d’activació de SIRT1 contra el deteriorament cognitiu a l’envelliment''

Dra. Coral Sanfeliu.

21 setembre 2012, 12:00h, Sala Miquel Servet.


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SEMINARIS IIBB 2012
data de publicació: 16/01/2012
''Alteració dels ritmes cerebrals per al·lucinògens. Relació amb l’esquizofrènia.''

Dra. Pau Celada.

26 octubre 2012, 12:00h, Sala Miquel Servet.


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SEMINARIS IIBB 2012
data de publicació: 13/01/2012
''Mitocondria y Enfermedad de Alzheimer''

Dra. Anna Colell.

23 novembre 2012, 12:00h, Sala Miquel Servet.


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